Raw data for mass spectrometry analysis of the effects of hypoxia on mitochondrial protein composition
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hela Cell
DISEASE(S): Cervix Carcinoma
SUBMITTER: 
Tianshu Hao
LAB HEAD: Zhiyin Song
PROVIDER: PXD034375 | Pride | 2023-10-24
REPOSITORIES: Pride
Publications
Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion.
Hao Tianshu T Yu Jianglong J Wu Zhida Z Jiang Jie J Gong Longlong L Wang Bingjun B Guo Hanze H Zhao Huabin H Lu Bin B Engelender Simone S He He H Song Zhiyin Z
Nature communications 20230711 1
Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative phosphorylation to generate ATP. Lysosomes contain hydrolytic enzymes that degrade misfolded proteins and damaged organelles to maintain cellular homeostasis. Mitochondria physically and functionally interact with lysosomes to regulate cellular metabolism. However, the mode and biological functions of mitochondria-lysosome communication remain largely unknown. Here, we show that hypoxia remodels normal tubular ...[more]
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