Raw data for mass spectrometry analysis of the effects of hypoxia on mitochondrial protein composition

ABSTRACT: This project wanted to demonstrate that mitoselfphagy degrades various mitochondrial proteins to a different extent. Therefore，we measured the levels of mitochondrial proteins under hypoxia by mass spectrometry analysis. After 24 hours of hypoxia, most mitochondrial proteins, locating at different mitochondrial compartments, were decreased to different extents relative to normoxic controls. After hypoxia, The certain mitochondrial proteins were increased, and some mitochondrial proteins remained almost unchanged. These data demonstrated that mitoselfphagy is different from traditional mitophagy that degrades the entire mitochondria, which degrades various mitochondrial proteins to a different extent.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hela Cell

DISEASE(S): Cervix Carcinoma

SUBMITTER: Tianshu Hao  

LAB HEAD: Zhiyin Song

PROVIDER: PXD034375 | Pride | 2023-10-24

REPOSITORIES: Pride