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Surface proteome profiling of p53-restorable murine liver cancer cells

ABSTRACT: Characterization of the surface proteome changes between proliferating and senescent liver cancer cells induced by p53 restoration.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Yu-Jui Ho

LAB HEAD: Scott Lowe

PROVIDER: PXD034465 | Pride | 2023-03-11

REPOSITORIES: Pride

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Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity.

Chen Hsuan-An HA Ho Yu-Jui YJ Mezzadra Riccardo R Adrover Jose M JM Smolkin Ryan R Zhu Changyu C Woess Katharina K Bernstein Nicholas N Schmitt Georgia G Fong Linda L Luan Wei W Wuest Alexandra A Tian Sha S Li Xiang X Broderick Caroline C Hendrickson Ronald C RC Egeblad Mikala M Chen Zhenghao Z Alonso-Curbelo Direna D Lowe Scott W SW

Cancer discovery 20230201 2

Cellular senescence involves a stable cell-cycle arrest coupled to a secretory program that, in some instances, stimulates the immune clearance of senescent cells. Using an immune-competent liver cancer model in which senescence triggers CD8 T cell-mediated tumor rejection, we show that senescence also remodels the cell-surface proteome to alter how tumor cells sense environmental factors, as exemplified by type II interferon (IFNγ). Compared with proliferating cells, senescent cells upregulate ...[more]

PMID: 36302222

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