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Identification of cell membrane proteins involved in dsRNA internalization

ABSTRACT: Cellular uptake of dsRNA from the environment is a widespread phenomenon among insects. In Drosophila and in honeybees, the injection and the ingestion respectively of dsRNA against a viral sequence is sufficient to hinder virus replication. We wanted to identify cell surface proteins that bind to extracellular dsRNA, mediating its internalization. To this end, we developed an unconventional co-immunoprecipitation protocol followed by proteomics analysis.

INSTRUMENT(S):

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

TISSUE(S): Cell Culture, Embryonic Stem Cell

SUBMITTER: Yann Verdier

LAB HEAD: Joelle Vinh

PROVIDER: PXD034508 | Pride | 2025-04-11

REPOSITORIES: Pride

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			Action	DRS
	1150_1151_1152_1153.mzid.gz	Mzid
	December.msfView	Msf
	December.pdResult	Other
	December.xlsx	Xlsx
	F091849.mgf	Mgf

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