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ITRAQ based proteomic analysis to reveal the mechanism of tigecycline resistance in Acinetobacter baumannii

ABSTRACT: The antibiotic resistance of A. baumannii has been increasing in recent years. There are still many questions unclear concerning the mechanism of tigecycline resistance in A. baumannii. iTRAQ based proteomic analysis were used to reveal the mechanism of tigecycline resistance in Acinetobacter baumannii.

INSTRUMENT(S): 6520 Quadrupole Time-of-Flight LC/MS

ORGANISM(S): Acinetobacter Baumannii

SUBMITTER: Qinghua Zou

LAB HEAD: Qinghua Zou

PROVIDER: PXD034784 | Pride | 2023-07-20

REPOSITORIES: Pride

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The Mechanism of Tigecycline Resistance in <i>Acinetobacter baumannii</i> Revealed by Proteomic and Genomic Analysis.

Liu Cunwei C Wang Lei L Wang Ping P Xiao Di D Zou Qinghua Q

International journal of molecular sciences 20230512 10

The mechanism of tigecycline resistance in <i>A. baumannii</i> remains largely unclear. In this study, we selected a tigecycline-resistant and a tigecycline-susceptible strain from a tigecycline-susceptible and a resistant strain, respectively. Proteomic and genomic analyses were performed to elucidate the variations associated with tigecycline resistance. Our study showed proteins associated with efflux pump, biofilm formation, iron acquisition, stress response, and metabolic ability are upregu ...[more]

PMID: 37239993

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