Ontology highlight
ABSTRACT:
INSTRUMENT(S): maXis
ORGANISM(S): Caenorhabditis Elegans
SUBMITTER: Bernd Thiede
LAB HEAD: Rafal Ciosk
PROVIDER: PXD034794 | Pride | 2022-10-14
REPOSITORIES: Pride
Nature communications 20220819 1
How animals rewire cellular programs to survive cold is a fascinating problem with potential biomedical implications, ranging from emergency medicine to space travel. Studying a hibernation-like response in the free-living nematode Caenorhabditis elegans, we uncovered a regulatory axis that enhances the natural resistance of nematodes to severe cold. This axis involves conserved transcription factors, DAF-16/FoxO and PQM-1, which jointly promote cold survival by upregulating FTN-1, a protein rel ...[more]