LC-MSMS of primary breast cancer samples
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Breast
DISEASE(S): Breast Cancer
SUBMITTER: 
Courcelles Mathieu
LAB HEAD: Pierre Thibault
PROVIDER: PXD034818 | Pride | 2023-11-15
REPOSITORIES: Pride
Publications
Breast cancer immunopeptidomes contain numerous shared tumor antigens.
Kina Eralda E Laverdure Jean-Philippe JP Durette Chantal C Lanoix Joël J Courcelles Mathieu M Zhao Qingchuan Q Apavaloaei Anca A Larouche Jean-David JD Hardy Marie-Pierre MP Vincent Krystel K Gendron Patrick P Hesnard Leslie L Thériault Catherine C Ruiz Cuevas Maria Virginia MV Ehx Grégory G Thibault Pierre P Perreault Claude C
The Journal of clinical investigation 20240102 1
Hormone receptor-positive breast cancer (HR+) is immunologically cold and has not benefited from advances in immunotherapy. In contrast, subsets of triple-negative breast cancer (TNBC) display high leukocytic infiltration and respond to checkpoint blockade. CD8+ T cells, the main effectors of anticancer responses, recognize MHC I-associated peptides (MAPs). Our work aimed to characterize the repertoire of MAPs presented by HR+ and TNBC tumors. Using mass spectrometry, we identified 57,094 unique ...[more]
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