Proteomic analysis of Dscc1 knockout mouse cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Embryo, Embryonic Stem Cell
SUBMITTER: 
James Wright
LAB HEAD: Jyoti Choudhary
PROVIDER: PXD034902 | Pride | 2023-11-17
REPOSITORIES: Pride
Publications
Genetic determinants of micronucleus formation in vivo.
Adams D J DJ Barlas B B McIntyre R E RE Salguero I I van der Weyden L L Barros A A Vicente J R JR Karimpour N N Haider A A Ranzani M M Turner G G Thompson N A NA Harle V V Olvera-León R R Robles-Espinoza C D CD Speak A O AO Geisler N N Weninger W J WJ Geyer S H SH Hewinson J J Karp N A NA Fu B B Yang F F Kozik Z Z Choudhary J J Yu L L van Ruiten M S MS Rowland B D BD Lelliott C J CJ Del Castillo Velasco-Herrera M M Verstraten R R Bruckner L L Henssen A G AG Rooimans M A MA de Lange J J Mohun T J TJ Arends M J MJ Kentistou K A KA Coelho P A PA Zhao Y Y Zecchini H H Perry J R B JRB Jackson S P SP Balmus G G
Nature 20240214 8002
Genomic instability arising from defective responses to DNA damage<sup>1</sup> or mitotic chromosomal imbalances<sup>2</sup> can lead to the sequestration of DNA in aberrant extranuclear structures called micronuclei (MN). Although MN are a hallmark of ageing and diseases associated with genomic instability, the catalogue of genetic players that regulate the generation of MN remains to be determined. Here we analyse 997 mouse mutant lines, revealing 145 genes whose loss significantly increases ( ...[more]
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