Dataset Information
Investigating proteome remodeling as a function of mammalian cell size
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Federico Uliana
LAB HEAD: Federico Uliana
PROVIDER: PXD034934 | Pride | 2024-01-26
REPOSITORIES: Pride
Publications
Genome homeostasis defects drive enlarged cells into senescence.
Molecular cell 20231116 22
Cellular senescence refers to an irreversible state of cell-cycle arrest and plays important roles in aging and cancer biology. Because senescence is associated with increased cell size, we used reversible cell-cycle arrests combined with growth rate modulation to study how excessive growth affects proliferation. We find that enlarged cells upregulate p21, which limits cell-cycle progression. Cells that re-enter the cell cycle encounter replication stress that is well tolerated in physiologicall ...[more]
