Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Leukocyte, Fibroblast
SUBMITTER: Andreas Hentschel
LAB HEAD: Andreas Hentschel
PROVIDER: PXD034993 | Pride | 2023-05-10
REPOSITORIES: Pride
Hentschel Andreas A Meyer Nancy N Kohlschmidt Nicolai N Groß Claudia C Sickmann Albert A Schara-Schmidt Ulrike U Förster Fabian F Töpf Ana A Christiansen Jon J Horvath Rita R Vorgerd Matthias M Thompson Rachel R Polavarapu Kiran K Lochmüller Hanns H Preusse Corinna C Hannappel Luis L Schänzer Anne A Grüneboom Anika A Gangfuß Andrea A Roos Andreas A
Molecular neurobiology 20230124 5
PPP1R21 acts as a co-factor for protein phosphatase 1 (PP1), an important serine/threonine phosphatase known to be essential for cell division, control of glycogen metabolism, protein synthesis, and muscle contractility. Bi-allelic pathogenic variants in PPP1R21 were linked to a neurodevelopmental disorder with hypotonia, facial dysmorphism, and brain abnormalities (NEDHFBA) with pediatric onset. Functional studies unraveled impaired vesicular transport as being part of PPP1R21-related pathomech ...[more]