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Medulloblastoma Patient-Derived Xenograft Proteomics

ABSTRACT: Proteomic and phosphoproteomic characterization of 20 orthotopic patient-derived xenograft models of medulloblastoma

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebellum, Brain

DISEASE(S): Medulloblastoma,Brain Cancer

SUBMITTER: Krystine Mansfield

LAB HEAD: Patrick Pirrotte

PROVIDER: PXD035070 | Pride | 2022-09-01

REPOSITORIES: Pride

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Publications

Subgroup-Enriched Pathways and Kinase Signatures in Medulloblastoma Patient-Derived Xenografts.

Leskoske Kristin L KL Garcia-Mansfield Krystine K Sharma Ritin R Krishnan Aparna A Rusert Jessica M JM Mesirov Jill P JP Wechsler-Reya Robert J RJ Pirrotte Patrick P

Journal of proteome research 20220817 9

Medulloblastoma (MB) is the most common malignant pediatric brain tumor. MB is classified into four primary molecular subgroups: wingless (WNT), sonic hedgehog (SHH), Group 3 (G3), and Group 4 (G4), and further genomic and proteomic subtypes have been reported. Subgroup heterogeneity and few actionable mutations have hindered the development of targeted therapies, especially for G3 MB, which has a particularly poor prognosis. To identify novel therapeutic targets for MB, we performed mass spectr ...[more]

PMID: 35977718

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