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Proteomic analysis of the secretome of a esxaA mutant Mycobacterium tuberculosis strain

ABSTRACT: Extracellular Mycobacterium tuberculosis (Mtb) aggregates can evade phagocytosis and intracellular host-cell defenses by inducing macrophage killing. We showed that Mtb aggregates require a functional ESX-1 type VII secretion system to induce cell death upon contact with macrophages. We used quantitative proteomics to compare the secretome of a esxA mutant strain with the wild type reference to identify secreted bacteria factors involved in macrophage death induction.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Mycobacterium Tuberculosis Bacteria

DISEASE(S): Tuberculosis

SUBMITTER: Chiara Toniolo

LAB HEAD: john McKinney

PROVIDER: PXD035082 | Pride | 2023-03-16

REPOSITORIES: Pride

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