Proteome of BaF3-mEpoR cells stimulated with 5 U/ml Epo, 10 ng/ml IL-3 or left untreated
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): B Cell
SUBMITTER: 
Alexander Held
LAB HEAD: Ursula Klingmüller
PROVIDER: PXD035181 | Pride | 2022-09-28
REPOSITORIES: Pride
Publications
Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo.
Chakraborty Sajib S Andrieux Geoffroy G Kastl Philipp P Adlung Lorenz L Altamura Sandro S Boehm Martin E ME Schwarzmüller Luisa E LE Abdullah Yomn Y Wagner Marie-Christine MC Helm Barbara B Gröne Hermann-Josef HJ Lehmann Wolf D WD Boerries Melanie M Busch Hauke H Muckenthaler Martina U MU Schilling Marcel M Klingmüller Ursula U
Cell reports 20220901 12
Erythropoietin (Epo) ensures survival and proliferation of colony-forming unit erythroid (CFU-E) progenitor cells and their differentiation to hemoglobin-containing mature erythrocytes. A lack of Epo-induced responses causes embryonic lethality, but mechanisms regulating the dynamic communication of cellular alterations to the organismal level remain unresolved. By time-resolved transcriptomics and proteomics, we show that Epo induces in CFU-E cells a gradual transition from proliferation signat ...[more]
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