Proteomics

Dataset Information

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Proteomic profiling of extracellular vesicles from cancer-associated fibroblast-induced myeloid-derived suppressor cells and related cell types


ABSTRACT: Cancer-associated fibroblast (CAF) promote immune suppression in the tumor microenvironment by polarizing monocytes to myeloid-derived suppressor cells (MDSC) that potently suppress T-cell function. Using a patient-derived coculture system, we found that extracellular vesicles (EV) released by CAF-induced MDSC directly suppress T-cell proliferation. In this study, we profiled the protein cargo of the EVs isolated from CAF-MDSC and compared to related cell types.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Myeloid Suppressor Cell

DISEASE(S): Lung Squamous Cell Carcinoma

SUBMITTER: Carlo Ramil  

LAB HEAD: An Chi

PROVIDER: PXD035248 | Pride | 2024-01-03

REPOSITORIES: Pride

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