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Effects of the differential K+ diets on mouse kidney cortex tissue

ABSTRACT: In this project, we investigated the global proteome alteration in mouse kidney cortex tissues after differential K+ diet treatments. TMTpro labeling strategy was used to obtain protein quantification information from LC-MS based proteomic analysis.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Kidney

SUBMITTER: Lei Cheng

LAB HEAD: Robert A. Fenton

PROVIDER: PXD035354 | Pride | 2023-05-10

REPOSITORIES: Pride

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Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation.

Little Robert R Murali Sathish K SK Poulsen Søren B SB Grimm Paul R PR Assmus Adrienne A Cheng Lei L Ivy Jessica R JR Hoorn Ewout J EJ Matchkov Vladimir V Welling Paul A PA Fenton Robert A RA

JCI insight 20230308 5

Dietary potassium (K+) supplementation is associated with a lowering effect in blood pressure (BP), but not all studies agree. Here, we examined the effects of short- and long-term K+ supplementation on BP in mice, whether differences depend on the accompanying anion or the sodium (Na+) intake and molecular alterations in the kidney that may underlie BP changes. Relative to the control diet, BP was higher in mice fed a high NaCl (1.57% Na+) diet for 7 weeks or fed a K+-free diet for 2 weeks. BP ...[more]

PMID: 36719746

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