Dataset Information
Contryphan sequence diversity:Conus virgo
Ontology highlight
ABSTRACT:
INSTRUMENT(S): maXis
ORGANISM(S): Conus Virgo
TISSUE(S): Venom Duct, Epithelial Cell
SUBMITTER: 
P Balaram
LAB HEAD: Prof.P.Balaram, Molecular Biophysics Unit.
PROVIDER: PXD035431 | Pride | 2023-02-01
REPOSITORIES: Pride
Publications
Contryphan sequence diversity: Messy N-terminus processing, effects on chromatographic behaviour and mass spectrometric fragmentation.
Journal of proteomics 20221229
Contryphans, peptides containing a single disulfide bond, are found abundantly in cone snail venom. The analysis of a large dataset of available contryphan sequences permits a classification based on the occurrence of proline residues at positions 2 and 5 within the macrocyclic 23-membered disulfide loop. Further sequence diversity is generated by variable proteolytic processing of the contryphan precursor proteins. In the majority of contryphans, presence of Pro at position 2 and a D-residue at ...[more]