Dataset Information

Proteomics Reveals the Wolframin-Calcium Axis as a Key Pathogenic Signaling Node in Primary Aldosteronism

ABSTRACT: Using 4D label-free quantitative proteomics technique, combined with bioinformatics, we generated in-depth proteome and phosphoproteome signaling network maps of aldosterone-producing adenoma and nonfunctioning adrenocortical tumor. We identified wolframin-calcium axis as a key regulatory node in aldosterone synthase activation and aldosterone hypersecretion.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Adrenal Adenoma Cell

SUBMITTER: 溢杨

LAB HEAD: Yang Yi

PROVIDER: PXD035656 | Pride | 2025-12-26

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	S9540LQ_A10_Slot2-24_1_2183.d.zip	Other
	S9540LQ_A1_Slot2-15_1_2163.d.zip	Other
	S9540LQ_A2_Slot2-16_1_2167.d.zip	Other
	S9540LQ_A3_Slot2-17_1_2169.d.zip	Other
	S9540LQ_A4_Slot2-18_1_2171.d.zip	Other

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Publications

Phosphoproteomics Reveals the Wolframin-Calcium Axis as an Important Pathogenic Signaling Node in Primary Aldosteronism.

Ma Linqiang L Yang Shumin S Yang Yi Y Chen Xiangjun X Yang Jun J He Yifan Y Cheng Qingfeng Q Li Junlong J Kang Bing B Tang Siying S Zhang Aipin A Shu Xiaoyu X Li Xiaoyu X Shen Hang H Jing Ying Y Song Ying Y Li Qifu Q Hu Jinbo J

Hypertension (Dallas, Tex. : 1979) 20230224 5

<h4>Background</h4>Aldosterone-producing adenoma (APA) is a benign adrenal tumor with autonomous aldosterone production which causes hypertension and excess cardiovascular risk. Protein phosphorylation regulates aldosterone secretion from adrenal cortical cells, but how signaling networks are remodeled in APA remains unknown.<h4>Methods</h4>We performed an integrated proteomic and phosphoproteomic profiling of 15 APA and 10 matched nonfunctioning adrenocortical tumors (NFAT) based on the 4-dimen ...[more]

PMID: 36825503

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