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Protein Disulfide Isomerase A6 Promotes Injured Nerve Repair through Interactions with Spastin

ABSTRACT: Here a proteomics analysis identified PDIA6 as being related to SCI repair.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Rattus Norvegicus (rat)

SUBMITTER: zhisheng Ji

LAB HEAD: Ji Zhisheng

PROVIDER: PXD035706 | Pride | 2022-10-15

REPOSITORIES: Pride

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Protein disulfide isomerase A6 promotes the repair of injured nerve through interactions with spastin.

Luo Jianxian J Xie Min M Peng Cheng C Ma Yanming Y Wang Ke K Lin Gengxiong G Yang Hua H Chen Tianjun T Liu Qiuling Q Zhang Guowei G Lin Hongsheng H Ji Zhisheng Z

Frontiers in molecular neuroscience 20220824

The maintenance of appropriate endoplasmic reticulum (ER) homeostasis is critical to effective spinal cord injury (SCI) repair. In previous reports, protein disulfide isomerase A6 (PDIA6) demonstrated to serve as a reversible functional modulator of ER stress responses, while spastin can coordinate ER organization through the modulation of the dynamic microtubule network surrounding this organelle. While both PDIA6 and spastin are thus important regulators of the ER, whether they interact with o ...[more]

PMID: 36090256

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