Dataset Information
Identification of AKTIP protein interaction partners in breast cancer cells MCF7
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Breast
DISEASE(S): Breast Cancer
SUBMITTER: 
Lydia Cheung
LAB HEAD: Dr CHEUNG, Lydia Wai Ting
PROVIDER: PXD035716 | Pride | 2023-01-02
REPOSITORIES: Pride
Publications
AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance.
Cell reports 20221201 11
Recurrent deletion of 16q12.2 is observed in luminal breast cancer, yet the causal genomic alterations in this region are largely unknown. In this study, we identify that loss of AKTIP, which is located on 16q12.2, drives tumorigenesis of estrogen receptor alpha (ERα)-positive, but not ERα-negative, breast cancer cells and is associated with poor prognosis of patients with ERα-positive breast cancer. Intriguingly, AKTIP-depleted tumors have increased ERα protein level and activity. Cullin-associ ...[more]
