Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Pseudomonas Sp. Bacteria
SUBMITTER: Todd Greco
LAB HEAD: Ileana M Cristea
PROVIDER: PXD035779 | Pride | 2022-09-06
REPOSITORIES: Pride
mBio 20220908 5
Pseudomonas aeruginosa is a human pathogen that relies on quorum sensing to establish infections. The PqsE quorum-sensing protein is required for P. aeruginosa virulence factor production and infection. PqsE has a reported enzymatic function in the biosynthesis of the quorum-sensing autoinducer called PQS. However, this activity is redundant because, in the absence of PqsE, this role is fulfilled by alternative thioesterases. Rather, PqsE drives P. aeruginosa pathogenic traits via a protein-prot ...[more]