Structural and proteomic repercussions of growth hormone receptor deficiency on the pituitary gland – lessons from a translational pig model

ABSTRACT: Growth hormone receptor deficiency (GHRD) results in low serum insulin-like growth factor 1 but high, non-functional GH levels. This study investigates the histomorphological and molecular alterations associated with GHRD. Pituitary glands from 6 months old GHR-KO pigs and control animals were compared using a quantitative stereological approach and label-free proteomics.

INSTRUMENT(S):

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Adenohypophysis

SUBMITTER: Bachuki Shashikadze  

LAB HEAD: Bachuki Shashikadze

PROVIDER: PXD035833 | Pride | 2023-05-12

REPOSITORIES: Pride