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Structural and proteomic repercussions of growth hormone receptor deficiency on the pituitary gland – lessons from a translational pig model

ABSTRACT: Growth hormone receptor deficiency (GHRD) results in low serum insulin-like growth factor 1 but high, non-functional GH levels. This study investigates the histomorphological and molecular alterations associated with GHRD. Pituitary glands from 6 months old GHR-KO pigs and control animals were compared using a quantitative stereological approach and label-free proteomics.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Adenohypophysis

SUBMITTER: Bachuki Shashikadze

LAB HEAD: Bachuki Shashikadze

PROVIDER: PXD035833 | Pride | 2023-05-12

REPOSITORIES: Pride

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Structural and proteomic repercussions of growth hormone receptor deficiency on the pituitary gland: Lessons from a translational pig model.

Shashikadze Bachuki B Franzmeier Sophie S Hofmann Isabel I Kraetzl Martin M Flenkenthaler Florian F Blutke Andreas A Fröhlich Thomas T Wolf Eckhard E Hinrichs Arne A

Journal of neuroendocrinology 20230415

Growth hormone receptor deficiency (GHRD) results in low serum insulin-like growth factor 1 (IGF1) and high, but non-functional serum growth hormone (GH) levels in human Laron syndrome (LS) patients and animal models. This study investigated the quantitative histomorphological and molecular alterations associated with GHRD. Pituitary glands from 6 months old growth hormone receptor deficient (GHR-KO) and control pigs were analyzed using a quantitative histomorphological approach in paraffin (9 G ...[more]

PMID: 37160285

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