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Human chorionic gonadotropin promotes murine Treg cells and restricts pregnancy-harmful proinflammatory Th17 responses – proteomics data

ABSTRACT: In this study, the participation of fetal factors in maintaining the immune balance during gestation was investigated by assessing the effects of human chorionic gonadotropin (hCG) on murine Treg cells and Th17 cells.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Isabel Karkossa

LAB HEAD: Kristin Schubert

PROVIDER: PXD035883 | Pride | 2022-10-14

REPOSITORIES: Pride

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Human chorionic gonadotropin promotes murine Treg cells and restricts pregnancy-harmful proinflammatory Th17 responses.

Lentz Lea S LS Stutz Annika J AJ Meyer Nicole N Schubert Kristin K Karkossa Isabel I von Bergen Martin M Zenclussen Ana C AC Schumacher Anne A

Frontiers in immunology 20220920

An equilibrium between proinflammatory and anti-inflammatory immune responses is essential for maternal tolerance of the fetus throughout gestation. To study the participation of fetal tissue-derived factors in this delicate immune balance, we analyzed the effects of human chorionic gonadotropin (hCG) on murine Treg cells and Th17 cells <i>in vitro</i>, and on pregnancy outcomes, fetal and placental growth, blood flow velocities and remodeling of the uterine vascular bed <i>in vivo</i>. Compared ...[more]

PMID: 36203576

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