Campylobacter jejuni MOMP carbene footprinting

ABSTRACT: Using carbene footprinting, we map the MOMP-QPLEX interaction and show by complementary in silico docking that QPLEX enters the porin channel through interactions at the extracellular face, translocates down the channel through a dipole transverse electric field towards the opposite end and is released into the periplasm at the intracellular face of MOMP. Our studies suggest a potential mechanism for the non-antibiotic anti-Campylobacter activity of these ferric chelates.

INSTRUMENT(S):

ORGANISM(S): Campylobacter Jejuni Subsp. Jejuni Nctc 11168-po

SUBMITTER: Jeddidiah Bellamy-Carter  

LAB HEAD: Neil J. Oldham

PROVIDER: PXD035978 | Pride | 2022-09-26

REPOSITORIES: Pride