Ctenopharyngodon idella, CIK cells, pull-down MS
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ABSTRACT: IL6-STAT3 is a canonical pro-inflammatory pathway that is highly related to temperature fluctuation and viral infection. Our understanding concerning how the crosstalk between IL6-STAT3 signaling axis and environmental temperature determines viral infection remains rudimentary. Employing an aquatic reovirus infection in ectotherms as a model system, we delineated a pivotal role of IL6-STAT3-HSP90 signaling axis in temperature dependent pathogenesis through interacting with viral capsid proteins to promote viral entry.
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Ctenopharyngodon Idella
TISSUE(S): Kidney
SUBMITTER: guoli hou
LAB HEAD: Guoli Hou
PROVIDER: PXD036006 | Pride | 2023-05-09
REPOSITORIES: Pride
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