Ctenopharyngodon idella, CIK cells, pull-down MS

ABSTRACT: IL6-STAT3 is a canonical pro-inflammatory pathway that is highly related to temperature fluctuation and viral infection. Our understanding concerning how the crosstalk between IL6-STAT3 signaling axis and environmental temperature determines viral infection remains rudimentary. Employing an aquatic reovirus infection in ectotherms as a model system, we delineated a pivotal role of IL6-STAT3-HSP90 signaling axis in temperature dependent pathogenesis through interacting with viral capsid proteins to promote viral entry.

INSTRUMENT(S):

ORGANISM(S): Ctenopharyngodon Idella

TISSUE(S): Kidney

SUBMITTER: guoli hou  

LAB HEAD: Guoli Hou

PROVIDER: PXD036006 | Pride | 2023-05-09

REPOSITORIES: Pride