Wnt/β-catenin and NFκB signaling synergize to trigger growth-factor-free regeneration of adult primary human hepatocytes

ABSTRACT: The liver has a remarkable capacity to regenerate, which is sustained by the ability of hepatocytes to act as facultative stem cells that, while normally quiescent, re-enter the cell cycle upon injury. In rodents, growth factor signaling is indispensable, whereas Wnt/β-catenin is not required for effective tissue repair. However, molecular networks controlling human liver regeneration remain unclear.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatocyte, Liver

SUBMITTER: Christian Beusch  

LAB HEAD: Volker M. Lauschke

PROVIDER: PXD036100 | Pride | 2024-05-22

REPOSITORIES: Pride