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Proteomics analysis of differentially expressed proteins in lung cancer H157 cells after overexpression of AACT with data‐independent acquisition mass spectrometry

ABSTRACT: H157 cells transfected with vector and overexpressed AACT plasmids were treated and used for MS detection. The MS data were acquired using an Orbitrap Exploris 480 Mass Spectrometer coupled with an EASY-NLC 1200 liquid phase LC-MS system. DIA raw data files were analyzed by DIA-NN software. The differentially expressed proteins were screened in this quantitative proteomics.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Yanxia Jin

LAB HEAD: Yanxia Jin

PROVIDER: PXD036119 | Pride | 2023-07-18

REPOSITORIES: Pride

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Overexpression of SERPINA3 suppresses tumor progression by modulating SPOP/NF‑κB in lung cancer.

Jin Yanxia Y Zhang Yueyang Y Huang Ankang A Chen Ying Y Wang Jinsong J Liu Na N Wang Xianping X Gong Yongsheng Y Wang Weidong W Pan Jicheng J

International journal of oncology 20230707 2

The pathogenesis mechanism of lung cancer is very complex, with high incidence and mortality. Serpin family A member 3 (SERPINA3) expression levels were reduced in the sera of patients with lung cancer and may be a candidate diagnostic and prognostic survival biomarker in lung cancer, as previously reported. However, the detailed biological functions of SERPINA3 in the pathogenesis of lung cancer remain unknown. In the present study, it was aimed to explore the effects of SERPINA3 on the occurre ...[more]

PMID: 37417362

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