Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): T Cell, Th17 Cell
SUBMITTER: Gerhard Mittler
LAB HEAD: Gerhard Mittler
PROVIDER: PXD036162 | Pride | 2022-10-13
REPOSITORIES: Pride
Baixauli Francesc F Piletic Klara K Puleston Daniel J DJ Villa Matteo M Field Cameron S CS Flachsmann Lea J LJ Quintana Andrea A Rana Nisha N Edwards-Hicks Joy J Matsushita Mai M Stanczak Michal A MA Grzes Katarzyna M KM Kabat Agnieszka M AM Fabri Mario M Caputa George G Kelly Beth B Corrado Mauro M Musa Yaarub Y Duda Katarzyna J KJ Mittler Gerhard G O'Sullivan David D Sesaki Hiromi H Jenuwein Thomas T Buescher Joerg M JM Pearce Edward J EJ Sanin David E DE Pearce Erika L EL
Nature 20220928 7932
CD4<sup>+</sup> T cell differentiation requires metabolic reprogramming to fulfil the bioenergetic demands of proliferation and effector function, and enforce specific transcriptional programmes<sup>1-3</sup>. Mitochondrial membrane dynamics sustains mitochondrial processes<sup>4</sup>, including respiration and tricarboxylic acid (TCA) cycle metabolism<sup>5</sup>, but whether mitochondrial membrane remodelling orchestrates CD4<sup>+</sup> T cell differentiation remains unclear. Here we show th ...[more]