Dataset Information
Thermal proteome profiling of ticagrelor in Staphylococcus aureus
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Staphylococcus Aureus
SUBMITTER: 
André Mateus
LAB HEAD: Athanasios Typas
PROVIDER: PXD036188 | Pride | 2024-01-26
REPOSITORIES: Pride
Publications
Systematic analysis of drug combinations against Gram-positive bacteria.
Nature microbiology 20230928 11
Drug combinations can expand options for antibacterial therapies but have not been systematically tested in Gram-positive species. We profiled ~8,000 combinations of 65 antibacterial drugs against the model species Bacillus subtilis and two prominent pathogens, Staphylococcus aureus and Streptococcus pneumoniae. Thereby, we recapitulated previously known drug interactions, but also identified ten times more novel interactions in the pathogen S. aureus, including 150 synergies. We showed that two ...[more]
