AP-PROTAC-2: a Photoswitchable multi-kinase PROTAC

ABSTRACT: Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Qisi Zhang  

LAB HEAD: Edward W. Tate

PROVIDER: PXD036224 | Pride | 2022-09-14

REPOSITORIES: Pride