AP-PROTAC-2: a Photoswitchable multi-kinase PROTAC
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ABSTRACT: Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Qisi Zhang
LAB HEAD: Edward W. Tate
PROVIDER: PXD036224 | Pride | 2022-09-14
REPOSITORIES: Pride
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