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Immunomodulatory effect of extracellular vesicles derived from Entamoeba histolytica trophozoites

ABSTRACT: We have isolated and characterized the extracellular vesicles released by Entamoeba histolytica, when alone or in coculture with human neutrophils, and determined their effect on human neutrophil NETs and ROS production.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human) Entamoeba Histolytica Hm-1:imss-a

TISSUE(S): Blood

SUBMITTER: Cesar Diaz

LAB HEAD: Julio Cesar Carrero

PROVIDER: PXD036228 | Pride | 2023-03-10

REPOSITORIES: Pride

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Immunomodulatory effect of extracellular vesicles from <i>Entamoeba histolytica</i> trophozoites: Regulation of NETs and respiratory burst during confrontation with human neutrophils.

Díaz-Godínez César C Ríos-Valencia Diana G DG García-Aguirre Samuel S Martínez-Calvillo Santiago S Carrero Julio César JC

Frontiers in cellular and infection microbiology 20221028

Parasites release extracellular vesicles (EVs) which, in some cases, modulate the host's immune response contributing to the establishment of the infection. In this work we have isolated and characterized the EVs released by trophozoites of the human protozoan parasite <i>Entamoeba histolytica</i>, the causal agent of amoebiasis, when alone or in coculture with human neutrophils, and determined their effect on neutrophil NETs and ROS production. Nanoparticle tracking analysis showed that amoebic ...[more]

PMID: 36389143

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