Mass spectrometry analysis of the neutrophil secretome (Gelatinase/Specific granules)
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Neutrophil, Blood
DISEASE(S): Inflammation
SUBMITTER: 
Sergio Catz
LAB HEAD: Sergio Daniel Catz
PROVIDER: PXD036270 | Pride | 2022-10-13
REPOSITORIES: Pride
Publications
Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammation.
Johnson Jennifer L JL Meneses-Salas Elsa E Ramadass Mahalakshmi M Monfregola Jlenia J Rahman Farhana F Carvalho Gontijo Raquel R Kiosses William B WB Pestonjamasp Kersi K Allen Dale D Zhang Jinzhong J Osborne Douglas G DG Zhu Yanfang Peipei YP Wineinger Nathan N Askari Kasra K Chen Danni D Yu Juan J Henderson Scott C SC Hedrick Catherine C CC Ursini Matilde Valeria MV Grinstein Sergio S Billadeau Daniel D DD Catz Sergio D SD
Nature communications 20220921 1
Dysregulated secretion in neutrophil leukocytes associates with human inflammatory disease. The exocytosis response to triggering stimuli is sequential; gelatinase granules modulate the initiation of the innate immune response, followed by the release of pro-inflammatory azurophilic granules, requiring stronger stimulation. Exocytosis requires actin depolymerization which is actively counteracted under non-stimulatory conditions. Here we show that the actin nucleator, WASH, is necessary to maint ...[more]
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