Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Rattus Norvegicus (rat)
DISEASE(S): Parkinson's Disease
SUBMITTER: Lei Zhou
LAB HEAD: Lei ZHOU
PROVIDER: PXD036335 | Pride | 2023-03-10
REPOSITORIES: Pride
Oey Nicodemus E NE Zhou Lei L Chan Christine Hui Shan CHS VanDongen Antonius M J AMJ Tan Eng King EK
Biomedicines 20230208 2
Synaptic dysfunction may underlie the pathophysiology of Parkinson's disease (PD), a presently incurable condition characterized by motor and cognitive symptoms. Here, we used quantitative proteomics to study the role of PHD Finger Protein 8 (PHF8), a histone demethylating enzyme found to be mutated in X-linked intellectual disability and identified as a genetic marker of PD, in regulating the expression of PD-related synaptic plasticity proteins. Amongst the list of proteins found to be affecte ...[more]