Proteomics

Dataset Information

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis

ABSTRACT: SARS-CoV-2 infection causes COVID-19, a severe acute respiratory disease associated with cardiovascular complications including long-term outcomes. The presence of virus in cardiac tissue of patients with COVID-19 suggests this is a direct, rather than secondary, effect of infection.Here, by expressing individual SARS-CoV-2 proteins in the Drosophila heart, we demonstrate interaction of virus Nsp6 with host proteins of the MGA/MAX complex (MGA, PCGF6 and TFDP1).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Mehari Weldemariam  

LAB HEAD: Maureen A. Kane

PROVIDER: PXD036447 | Pride | 2022-10-04

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
PXD036447_community_annotated.sdrf.tsv Tabular
ZH_JGL_SARS-CoV-2_IP_2ug_WH_081120.msf Msf
ZH_JGL_SARS-CoV-2_IP_2ug_WH_081120.pdResult Other
ZH_JGL_SARS-CoV-2_IP_2ug_WH_081120_01.raw Raw
ZH_JGL_SARS-CoV-2_IP_2ug_WH_081120_02.raw Raw
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