The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors

ABSTRACT: RUVBL2 is most important AAA+ ATPase for RNA polymerase II assembly and transcription regulation, through DNA remodeling or by directly interaction with PIC，this study will comprehensively to study the promiscuous functions of this proteins through the ChIP-MS, ChIP-seq, RNA-seq and nascent RNA seq and biochemistry analysis. Our study would provide more systematic and novel responsibility of this molecule, especially for the development and carcinomas.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Embryonic Stem Cell

SUBMITTER: Hui Wang  

LAB HEAD: Xiong Ji

PROVIDER: PXD036528 | Pride | 2022-09-29

REPOSITORIES: Pride