Dataset Information

Succinate mediates inflammation-induced adrenocortical dysfunction

ABSTRACT: Inflammation leads the hypothalamus-pituitary-adrenal (HPA) axis activation and increased production of glucocorticoids, which produced by the adrenal cortex, exert potent anti-inflammatory effects. The use of omics, including proteomics revealed metabolic changes in steroidogenic adrenocortical cells, including downregulation of the tricarboxylic acid (TCA) cycle and oxidative phosphorylation, decreased ATP production and induction of oxidative stress after lipopolysaccharide (LPS)-induced inflammation.

INSTRUMENT(S): timsTOF Pro 2

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Adrenal Gland

SUBMITTER: Evangelia Thanou

LAB HEAD: Ka Wan Li

PROVIDER: PXD036542 | Pride | 2023-07-21

REPOSITORIES: Pride

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Publications

Succinate mediates inflammation-induced adrenocortical dysfunction.

Mateska Ivona I Witt Anke A Hagag Eman E Sinha Anupam A Yilmaz Canelif C Thanou Evangelia E Sun Na N Kolliniati Ourania O Patschin Maria M Abdelmegeed Heba H Henneicke Holger H Kanczkowski Waldemar W Wielockx Ben B Tsatsanis Christos C Dahl Andreas A Walch Axel Karl AK Li Ka Wan KW Peitzsch Mirko M Chavakis Triantafyllos T Alexaki Vasileia Ismini VI

eLife 20230714

The hypothalamus-pituitary-adrenal (HPA) axis is activated in response to inflammation leading to increased production of anti-inflammatory glucocorticoids by the adrenal cortex, thereby representing an endogenous feedback loop. However, severe inflammation reduces the responsiveness of the adrenal gland to adrenocorticotropic hormone (ACTH), although the underlying mechanisms are poorly understood. Here, we show by transcriptomic, proteomic, and metabolomic analyses that LPS-induced systemic in ...[more]

PMID: 37449973

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Dataset Information

Succinate mediates inflammation-induced adrenocortical dysfunction

Publications

Succinate mediates inflammation-induced adrenocortical dysfunction.

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