NP-6A4 activates a novel signaling network of protective autophagy in obese female rat heart and attenuates cardiac dysfunction and coronary microvascular damage
Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Rattus Rattus (black Rat)
TISSUE(S): Heart
SUBMITTER: 
Brian Mooney
LAB HEAD: Lakshmi Pulakat
PROVIDER: PXD036596 | Pride | 2023-09-25
REPOSITORIES: Pride
Publications
Cardiovascular Protective Effects of NP-6A4, a Drug with the FDA Designation for Pediatric Cardiomyopathy, in Female Rats with Obesity and Pre-Diabetes.
Belenchia Anthony M AM Boukhalfa Asma A DeMarco Vincent G VG Mehm Alexander A Mahmood Abuzar A Liu Pei P Tang Yinian Y Gavini Madhavi P MP Mooney Brian B Chen Howard H HH Pulakat Lakshmi L
Cells 20230512 10
<h4>Background</h4>Obese and pre-diabetic women have a higher risk for cardiovascular death than age-matched men with the same symptoms, and there are no effective treatments. We reported that obese and pre-diabetic female Zucker Diabetic Fatty (ZDF-F) rats recapitulate metabolic and cardiac pathology of young obese and pre-diabetic women and exhibit suppression of cardio-reparative AT2R. Here, we investigated whether NP-6A4, a new AT2R agonist with the FDA designation for pediatric cardiomyopat ...[more]
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