Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Pancreas Development
DISEASE(S): Type 2 Diabetes Mellitus
SUBMITTER: Martin R. Larsen
LAB HEAD: Nils Billestrup
PROVIDER: PXD036655 | Pride | 2023-07-20
REPOSITORIES: Pride
Urizar Adriana Ibarra AI Prause Michala M Ingerslev Lars Roed LR Wortham Matthew M Sui Yinghui Y Sander Maike M Williams Kristine K Barrès Romain R Larsen Martin R MR Christensen Gitte Lund GL Billestrup Nils N
Cell death & disease 20230705 7
Insufficient insulin secretion is a hallmark of type 2 diabetes and has been attributed to beta cell identity loss characterized by decreased expression of several key beta cell genes. The pro-inflammatory factor BMP-2 is upregulated in islets of Langerhans from individuals with diabetes and acts as an inhibitor of beta cell function and proliferation. Exposure to BMP-2 induces expression of Id1-4, Hes-1, and Hey-1 which are transcriptional regulators associated with loss of differentiation. The ...[more]