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Proteomic signatures of the serological response to flu vaccination in a large human cohort study

ABSTRACT: This project investigates the serum proteomic signatures of the serological response to flu vaccination. We profiled the serum proteome of 160 flu vaccine recipients from a cohort study conducted in 2019-2020 season, with DIA-MS based proteomics. We compared the protein level between low and high responders based on the response measure seroconversion, as well as the adjusted seroconversion which excludes the confoudning effects of all the semographic factors recorded for these participants. We did the analysis for the composite seroconversion as well as for the individual strains. We also investigated the complex impact of age.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

SUBMITTER: Shaohuan Wu

LAB HEAD: Christine Vogel

PROVIDER: PXD036718 | Pride | 2022-11-17

REPOSITORIES: Pride

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Proteomic Signatures of the Serological Response to Influenza Vaccination in a Large Human Cohort Study.

Wu Shaohuan S Pushalkar Smruti S Maity Shuvadeep S Pressler Matthew M Rendleman Justin J Vitrinel Burcu B Carlock Michael M Ross Ted T Choi Hyungwon H Vogel Christine C

Viruses 20221109 11

The serological response to the influenza virus vaccine is highly heterogeneous for reasons that are not entirely clear. While the impact of demographic factors such as age, body mass index (BMI), sex, prior vaccination and titer levels are known to impact seroconversion, they only explain a fraction of the response. To identify signatures of the vaccine response, we analyzed 273 protein levels from 138 serum samples of influenza vaccine recipients (2019-2020 season). We found that levels of pro ...[more]

PMID: 36366577

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