Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
DISEASE(S): Breast Cancer
SUBMITTER: Justinne Guarin
LAB HEAD: Madeleine J Oudin
PROVIDER: PXD036736 | Pride | 2022-10-05
REPOSITORIES: Pride
Guarin Justinne R JR Fatherree Jackson P JP Oudin Madeleine J MJ
Matrix biology : journal of the International Society for Matrix Biology 20220805
Metastasis accounts for 90% of cancer-related deaths, yet the mechanisms by which cancer cells colonize secondary organs remain poorly understood. For breast cancer patients, metastasis to the liver is associated with poor prognosis and a median survival of 6 months. Standard of care is chemotherapy, but recurrence occurs in 30% of patients. Systemic chemotherapy has been shown to induce hepatotoxicity and fibrosis, but how chemotherapy impacts the composition of the liver extracellular matrix ( ...[more]