Proteomics

Dataset Information

0

DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation and metabolic remodeling


ABSTRACT: Using stable cell lines, we found that succinylation levels were highly dependent on DLST. Furthermore, PPGL-causing DLST mutations, predicted to alter DLST homo-oligomeric complex structure, caused a significant remodeling of the cellular succinylome. Succinylation is thought to cause major chemical and structural changes in proteins, most likely influencing their function. Accordingly, we found that the dysregulation of succinylation appeared to influence several essential pathways related to PPGL development such as hypoxia, glycolysis and oxidative phosphorylation. This study points to succinylation as a new mechanism involved in the development of PPGLs, supporting the growing body of research highlighting the role of this PTM in different types of cancer.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

DISEASE(S): Pheochromocytoma

SUBMITTER: Fernando Garcia  

LAB HEAD: Fernando Garcia Martinez

PROVIDER: PXD036782 | Pride | 2023-05-04

REPOSITORIES: Pride

Similar Datasets

2019-09-09 | PXD013664 | Pride
2019-01-23 | PXD012089 | Pride
2018-05-16 | PXD008728 | Pride
2022-11-09 | PXD033341 | Pride
2022-11-09 | PXD030190 | Pride
2021-11-03 | PXD025622 | Pride
2021-04-26 | PXD012149 | Pride
2021-10-29 | PXD025621 | Pride
2021-09-08 | PXD012814 | Pride
2022-10-14 | PXD032918 | Pride