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Human gastric cancer cell AGS shTOPK LC-MSMS

ABSTRACT: Knockdown of TOPK expression in human gastric cancer cells AGS, Phosphoproteomic assay for control and shTOPK groups

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: sanfei peng

LAB HEAD: Yang Fu

PROVIDER: PXD036814 | Pride | 2023-05-10

REPOSITORIES: Pride

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FYN/TOPK/HSPB1 axis facilitates the proliferation and metastasis of gastric cancer.

Peng SanFei S Yin YuHan Y Zhang YiZheng Y Zhu Feng F Yang Ge G Fu Yang Y

Journal of experimental & clinical cancer research : CR 20230404 1

<h4>Background</h4>FYN is a nonreceptor tyrosine kinase that regulates diverse pathological processes. The pro-cancer role of FYN in multiple malignancies has been elucidated. However, the mechanisms that FYN promotes gastric cancer (GC) progression remain largely unknown.<h4>Methods</h4>In vitro and in vivo assays were used to investigate the function of FYN. FYN, TOPK, p-TOPK expression in GC specimens were detected by immunohistochemistry. Phosphoproteomics assays identify TOPK downstream sub ...[more]

PMID: 37016377

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