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Viperin Mediates Coxsackievirus B3-induced Acute Heart Failure via KCNQ1 Ion Channel

ABSTRACT: Given that CVB3 is able to impair myocardial contractility, which finally leads to acute heart failure (AHF) and even sudden death, we tried to analyze the related myocardial function of these groups of mice

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

SUBMITTER: Xiaoyang Chen

LAB HEAD: Yukang Yuan

PROVIDER: PXD036898 | Pride | 2025-05-06

REPOSITORIES: Pride

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			Action	DRS
	ED271TQ.zip	Other
	ED271TQ_Fr1.raw	Raw
	ED271TQ_Fr10.raw	Raw
	ED271TQ_Fr11.raw	Raw
	ED271TQ_Fr12.raw	Raw

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Publications

Targeting Viperin prevents coxsackievirus B3-induced acute heart failure.

Yuan Yukang Y Qian Liping L Miao Ying Y Cui Qun Q Cao Ting T Yu Yong Y Zhang Tingting T Zhao Qian Q Zhang Renxia R Ren Tengfei T Zuo Yibo Y Du Qian Q Qiao Caixia C Wu Qiuyu Q Zheng Zhijin Z Li Minqi M Chinn Y Eugene YE Xu Wei W Peng Tianqing T Chen Ruizhen R Xiong Sidong S Zheng Hui H

Cell discovery 20250408 1

Coxsackievirus B3 (CVB3)-induced acute heart failure (AHF) is a common cause of cardiogenic death in young- and middle-aged people. However, the key molecular events linking CVB3 to AHF remain largely unknown, resulting in a lack of targeted therapy strategies thus far. Here, we unexpectedly found that Viperin deficiency does not promote CVB3 infection but protects mice from CVB3-induced AHF. Importantly, cardiac-specific expression of Viperin can induce cardiac dysfunction. Mechanistically, CVB ...[more]

PMID: 40195316

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F1Fo-ATP synthase subunit determines lethal infection in pathogenic fungi

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2021-09-16 | PXD024729 | Pride

TMT-based proteomic analysis and protein expression during excystation of Cryptosporidium andersoni

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2022-02-16 | PXD028423 | Pride

Comparative analysis of serum proteins between hepatitis B virus genotype B and C infection DIA-based quantitative proteomics

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Serum proteomic profiling in patients with advanced Schistosoma japonicum-induced hepatic fibrosis

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2022-09-06 | PXD025224 | Pride

Proteome and phosphoproteome of hippocampus after focal cerebral ischemia 2 h in mice

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