Proteomics

Dataset Information

0

TMT-based phosphoproteomics and proteomics analysis in Stk33-/- mouse testis

ABSTRACT: The phosphoproteome and proteome changes were quantified in Stk33-/- mouse testis using TMT 6-plex by LC-MS/MS.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Testis

SUBMITTER: xiangzheng zhang  

LAB HEAD: xuejiang guo

PROVIDER: PXD036903 | Pride | 2023-07-20

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
MaxQuant_1.6.2.10.zip Other
MaxQuant_1.6.5.0.zip Other
TMT_95minCoon_ExpressionProfileTestisStk33_20190330.zip Other
TMT_95minCoon_ExpressionProfileTestisStk33_fraction10_20190331.raw Raw
TMT_95minCoon_ExpressionProfileTestisStk33_fraction11_20190331.raw Raw
Items per page:
1 - 5 of 44
altmetric image

Publications

STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in Spermiogenesis.

Yu Weiling W   Li Yang Y   Chen Hong H   Cui Yiqiang Y   Situ Chenghao C   Yao Liping L   Zhang Xiangzheng X   Lu Shuai S   Liu Li L   Li Laihua L   Ren Jie J   Guo Yueshuai Y   Huo Zian Z   Chen Yu Y   Li Haojie H   Jiang Tao T   Gu Yayun Y   Wang Cheng C   Zhu Tianyu T   Li Yan Y   Hu Zhibin Z   Guo Xuejiang X  

Molecular & cellular proteomics : MCP 20230503 6

Spermatogenesis defects are important for male infertility; however, the etiology and pathogenesis are still unknown. Herein, we identified two loss-of-function mutations of STK33 in seven individuals with non-obstructive azoospermia. Further functional studies of these frameshift and nonsense mutations revealed that Stk33<sup>-/KI</sup> male mice were sterile, and Stk33<sup>-/KI</sup> sperm were abnormal with defects in the mitochondrial sheath, fibrous sheath, outer dense fiber, and axoneme. S  ...[more]

Similar Datasets

Proteomics Phosphoproteomic analysis of neonatal regenerative myocardium revealed important roles of CHK1 via activating mTORC1/P70S6K pathway
2020-02-28 | PXD014865 | Pride
Proteomics TMT-based phosphoproteomics and proteomics analysis of the developing mouse heart
2023-01-17 | PXD036824 | Pride
Proteomics TMT-based proteomics and phosphoproteomics analysis of proteome changes in seminal plasma extracellular vesicles of azoospermia
2021-09-09 | PXD022843 | Pride
Proteomics TMT-based proteomics analysis of mouse germ cells
2022-10-05 | PXD020874 | Pride
Proteomics Pig liver postnatal vs adult proteome analysis
2023-07-17 | PXD037264 | Pride
Transcriptomics Expression Analysis of Trimethyltin Chlorides (TMT) Impact on Embryonic Development
2011-03-23 | E-GEOD-28131 | biostudies-arrayexpress
Transcriptomics Transcription profiling of rat at pheochromocytoma cell line PC12 treated with trimethyltin at low and high doses
2009-04-29 | E-GEOD-5073 | biostudies-arrayexpress
Proteomics TMT-based phosphoproteomics and proteomics analysis of spermatids
2025-12-08 | PXD063123 | Pride
Proteomics TMT-based phosphoproteomics analysis of Ttbk2sko mouse testis
2025-12-08 | PXD063193 | Pride
Transcriptomics Methylation profiling in colorectal cancer
2012-03-10 | E-GEOD-36380 | biostudies-arrayexpress