Identification of substrates of ZDHHC20 in a mouse pancreatic carcinoma cell line
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ABSTRACT: An shRNA screen to search for the mediators of pancreatic cancer metastasis identified palmitoyl transferase ZDHHC20 as a protein that mediates this process by promoting the outgrowth of metastatic cells in vivo. We sought to identify the substrates of ZDHHC20 by using an engineered mutant of ZDHHC20 with a Y181G substitution, which can selectively accommodate a synthetic lipid probe and transfer it to a protein substrate.
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Pancreatic Cancer
SUBMITTER: Goran Tomic
LAB HEAD: Julian Downward
PROVIDER: PXD036914 | Pride | 2023-02-09
REPOSITORIES: Pride
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