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TMT proteomics analysis of B16/F10

ABSTRACT: The recently described role of RNA methylation in regulating immune cell infiltration into tumors has attracted interest, given its potential impact on immunotherapy response. YTHDF1 is a versatile and powerful m6A reader, but the understanding of its impact on immune evasion is limited. Here, we revealed that tumor-intrinsic Ythdf1 drives immune evasion and immune checkpoint inhibitor (ICI) resistance. TMT proteomics analysis was performed to identify the altered protein.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Melanocyte

DISEASE(S): Melanoma

SUBMITTER: Wanzun Lin

LAB HEAD: Wanzun Lin

PROVIDER: PXD036938 | Pride | 2022-12-06

REPOSITORIES: Pride

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