Dataset Information

Isolation and Characterization of ZK002, A Novel Dual Function Snake Venom Peptide from Deinagkistrodon acutus with Anti-angiogenic and Anti-inflammatory Properties

ABSTRACT: Pathological angiogenesis, the abnormal or excessive generation of blood vessels, plays an important role in many diseases including cancer, diabetic retinopathy, psoriasis, and arthritis. Additionally, increasing evidence supports the close linkage between angiogenesis and inflammation. Snake venoms are a rich natural source of biologically active molecules and carry rich potential for the discovery anti-angiogenic and anti-inflammatory modulators. Here, we isolated and purified a novel protein, ZK002, from the venom of the snake Deinagkistrodon acutus, and investigated its anti-angiogenic and anti-inflammatory activities and mechanisms.

INSTRUMENT(S):

ORGANISM(S): Deinagkistrodon Acutus

TISSUE(S): Venom

SUBMITTER: William Chi-Shing Tai