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TLK1 phosphorylates human RAD54

ABSTRACT: TLK1 phosphorylates RAD54 at novel residues -T41, T59, T700

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Arrigo DeBenedetti

LAB HEAD: Arrigo DeBenedetti

PROVIDER: PXD037131 | Pride | 2023-10-24

REPOSITORIES: Pride

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TLK1-mediated RAD54 phosphorylation spatio-temporally regulates Homologous Recombination Repair.

Ghosh Ishita I Kwon Youngho Y Shabestari Aida Badamchi AB Chikhale Rupesh R Chen Jing J Wiese Claudia C Sung Patrick P De Benedetti Arrigo A

Nucleic acids research 20230901 16

Environmental agents like ionizing radiation (IR) and chemotherapeutic drugs can cause severe damage to the DNA, often in the form of double-strand breaks (DSBs). Remaining unrepaired, DSBs can lead to chromosomal rearrangements, and cell death. One major error-free pathway to repair DSBs is homologous recombination repair (HRR). Tousled-like kinase 1 (TLK1), a Ser/Thr kinase that regulates the DNA damage checkpoint, has been found to interact with RAD54, a central DNA translocase in HRR. To det ...[more]

PMID: 37439356

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