Precision Characterization of Site-specific O-Acetylated Sialic Acids on N-Glycoproteins

ABSTRACT: O-Acetylation is a common modification of sialic acid, playing a significant role in glycoprotein stability, immune response, and cell development. The lack of efficient methods for direct analysis of O-acetylated sialoglycopeptides (O-AcSGPs) made the majority of identified O-acetylated sialic acids (O-AcSia) till now had no glycosite/glycoprotein information. Herein, we introduced a new workflow for precise interpretation of O-AcSGPs with probability estimation by recognizing the characteristic B and Y ions of O-AcSias.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Serum

SUBMITTER: Jiechen Shen  

LAB HEAD: Shisheng Sun

PROVIDER: PXD037161 | Pride | 2023-01-13

REPOSITORIES: Pride