Dataset Information

PITX2 defiency identifies changes in sarcomere structure and mitochondrial dysfunktion as substrates for atrial fibrillation

ABSTRACT: Atrial fibrillation affects 2-3% of the population and is associated with high morbidity and mortality from cardiovascular causes in patients. Common gene variants on chromosome 4q25 show the strongest genomic disease association and reside in an enhancer region regulating the Paired like Homeodomain 2 (PITX2) gene. Mechanisms how PITX2 is linked with AF remains unknown. Differences in protein abundance was compared in PITX2 knockout human induced pluripotent stem cell-derived atrial cardiomyocytes and their respective isogenic controls from six independent differentiation runs.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Adult Stem Cell Line, Cardiocyte

DISEASE(S): Atrial Fibrillation

SUBMITTER: Sönke Harder

LAB HEAD: Fiederike Cuello

PROVIDER: PXD037189 | Pride | 2025-05-06

REPOSITORIES: Pride

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Publications

PITX2 deficiency leads to atrial mitochondrial dysfunction.

Reyat Jasmeet S JS Sommerfeld Laura C LC O'Reilly Molly M Roth Cardoso Victor V Thiemann Ellen E Khan Abdullah O AO O'Shea Christopher C Harder Sönke S Müller Christian C Barlow Jonathan J Stapley Rachel J RJ Chua Winnie W Kabir S Nashitha SN Grech Olivia O Hummel Oliver O Hübner Norbert N Kääb Stefan S Mont Lluis L Hatem Stéphane N SN Winters Joris J Zeemering Stef S Morgan Neil V NV Rayes Julie J Gehmlich Katja K Stoll Monika M Brand Theresa T Schweizer Michaela M Piasecki Angelika A Schotten Ulrich U Gkoutos Georgios V GV Lorenz Kristina K Cuello Friederike F Kirchhof Paulus P Fabritz Larissa L

Cardiovascular research 20241201 15

<h4>Aims</h4>Reduced left atrial PITX2 is associated with atrial cardiomyopathy and atrial fibrillation (AF). PITX2 is restricted to left atrial cardiomyocytes (aCMs) in the adult heart. The links between PITX2 deficiency, atrial cardiomyopathy, and AF are not fully understood.<h4>Methods and results</h4>To identify mechanisms linking PITX2 deficiency to AF, we generated and characterized PITX2-deficient human aCMs derived from human induced pluripotent stem cells (hiPSC) and their controls. PIT ...[more]

PMID: 39129206

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			Action	DRS
	220829_sh_FC_A1.mzML	Mzml
	220829_sh_FC_A1_to_B6_Quant.msf	Msf
	220829_sh_FC_A2.mzML	Mzml
	220829_sh_FC_A3.mzML	Mzml
	220829_sh_FC_A4.mzML	Mzml