Proteomics

Dataset Information

LFQ proteomics analysis of M. smegmatis treated with CymA and ecumicin (Part 1).

ABSTRACT: To assess the impact of the bactericidal compounds CymA and ecumicin on the mycobacterial proteome and to monitor proteome remodeling by the AAA+ ClpC1 protease machinery, we performed a LFQ proteomics analysis treating the cells at sub-bactericidal compound concentration. We identified new players of the mycobacterial ClpC1 stress response (ClpC2 and ClpC3), as novel bacterial antibiotic resistance mechanism.

INSTRUMENT(S):

ORGANISM(S): Mycobacterium Smegmatis (strain Atcc 700084 / Mc(2)155)

SUBMITTER: David Hoi  

LAB HEAD: Markus Hartl

PROVIDER: PXD037232 | Pride | 2023-06-07

REPOSITORIES: Pride

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Dataset's files

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Action DRS
20191017_Lumos_RSLC6_Hoi_Clausen_IMP_msm_comptest_a1_0.msf Msf
20191017_Lumos_RSLC6_Hoi_Clausen_IMP_msm_comptest_a1_0.mzML Mzml
20191017_Lumos_RSLC6_Hoi_Clausen_IMP_msm_comptest_a1_0.raw Raw
20191017_Lumos_RSLC6_Hoi_Clausen_IMP_msm_comptest_a1_2h.msf Msf
20191017_Lumos_RSLC6_Hoi_Clausen_IMP_msm_comptest_a1_2h.mzML Mzml
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