Human Prostate Cancer epithelial-fibroblast cell signalling by CTAP-MS

ABSTRACT: A greater understanding of cell signaling events that occur within the prostate cancer tumor microenvironment (TME), for example between cancer-associated fibroblasts (CAFs) and prostate epithelial or cancer cells, may identify novel biomarkers and more effective therapeutic strategies for this disease. To address this, we used cell-type specific labelling with amino acid precursors (CTAP) to define cell type-specific phosphoproteomic changes that occur when prostate epithelial cells are co-cultured with normal patient-derived prostate fibroblasts (NPFs) versus matched CAFs.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Testis, Epithelial Cell

DISEASE(S): Prostate Adenocarcinoma

SUBMITTER: Terry Lim  

LAB HEAD: Roger Daly

PROVIDER: PXD037272 | Pride | 2023-03-11

REPOSITORIES: Pride